The Center for Computational Sciences and Engineering (CCSE) develops and applies advanced computational methodologies to solve large-scale scientific and engineering problems arising in the Department of Energy (DOE) mission areas involving energy, environment, and industrial technology. CCSE researchers design algorithms for multiscale, multiphysics problems described by nonlinear systems of partial differential equations, and develop classical and data-driven algorithms that target current and next-generation massively parallel computational architectures. Sample application areas include complex fluids for industry and mesoscale applications, atmospheric and ocean modeling, plasma applications, microelectronics applications, epidemiology, and cosmology CCSE researchers work collaboratively with application scientists to develop state-of-the-art solution methodologies in these fields.